EC |
3.4.17.3 |
Accepted name: |
lysine carboxypeptidase |
Reaction: |
Release of a C-terminal basic amino acid, preferentially lysine |
Other name(s): |
carboxypeptidase N; arginine carboxypeptidase; kininase I; anaphylatoxin inactivator; plasma carboxypeptidase B; creatine kinase conversion factor; bradykinase; kininase Ia; hippuryllysine hydrolase; bradykinin-decomposing enzyme; protaminase; CPase N; creatinine kinase convertase; peptidyl-L-lysine(-L-arginine) hydrolase; CPN |
Comments: |
A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9013-89-2 |
References: |
1. |
Plummer, T.H., Jr. and Erdös, E.G. Human plasma carboxypeptidase N. Methods Enzymol. 80 (1981) 442–449. [PMID: 7341915] |
2. |
Levin, Y., Skidgel, R.A. and Erdös, E.G. Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase I). Proc. Natl. Acad. Sci. USA 79 (1982) 4618–4622. [DOI] [PMID: 6750606] |
3. |
Skidgel, R.A. Basic carboxypeptidases: regulators of peptide hormone activity. Trends Pharmacol. Sci. 9 (1988) 301–303. [DOI] [PMID: 3074547] |
|
[EC 3.4.17.3 created 1972 as EC 3.4.12.7, transferred 1978 to EC 3.4.17.3, modified 1989] |
|
|
|
|