| EC |
3.4.21.10 |
| Accepted name: |
acrosin |
| Reaction: |
Preferential cleavage: Arg┼, Lys┼ |
| Other name(s): |
acrosomal proteinase; acrozonase; α-acrosin; β-acrosin; upsilon-acrosin; acrosomal protease; acrosin amidase |
| Comments: |
Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9068-57-9 |
| References: |
| 1. |
Müller-Esterl, W. and Fritz, H. Sperm acrosin. Methods Enzymol. 80 (1981) 621–632. [PMID: 7043204] |
| 2. |
Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P. The specificity of two proteinases that cleave adjacent to arginine, C 1 esterase and acrosin, for peptide p-nitroanilide substrates. Biochim. Biophys. Acta 996 (1989) 89–94. [DOI] [PMID: 2500154] |
| 3. |
Keime, S., Adham, I.M. and Engel, W. Nucleotide sequence and exon-intron organisation of the human proacrosin gene. Eur. J. Biochem. 190 (1990) 195–200. [DOI] [PMID: 2114285] |
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| [EC 3.4.21.10 created 1972] |
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