ExplorEnz: EC 3.4.21.121

Your query returned 1 entry. Printable version

3.4.21.121

Accepted name:

Lys-Lys/Arg-Xaa endopeptidase

Reaction:

Cleavage of -Lys-Lys┼ and -Lys-Arg┼ bonds.

Other name(s):

ASP (Aeromonas sobria)-type peptidase; Aeromonas extracellular serine protease

Comments:

The enzyme is a serine peptidase, which has been shown to cleave prothrombin and prekallikrein. It hydrolyses the complement component C5 releasing complement component C5a.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Kobayashi, H., Utsunomiya, H., Yamanaka, H., Sei, Y., Katunuma, N., Okamoto, K. and Tsuge, H. Structural basis for the kexin-like serine protease from Aeromonas sobria as sepsis-causing factor. J. Biol. Chem. 284 (2009) 27655–27663. [DOI] [PMID: 19654332]
2.	Nitta, H., Kobayashi, H., Irie, A., Baba, H., Okamoto, K. and Imamura, T. Activation of prothrombin by ASP, a serine protease released from Aeromonas sobria. FEBS Lett. 581 (2007) 5935–5939. [DOI] [PMID: 18067862]
3.	Kobayashi, H., Takahashi, E., Oguma, K., Fujii, Y., Yamanaka, H., Negishi, T., Arimoto-Kobayashi, S., Tsuji, T. and Okamoto, K. Cleavage specificity of the serine protease of Aeromonas sobria, a member of the kexin family of subtilases. FEMS Microbiol. Lett. 256 (2006) 165–170. [DOI] [PMID: 16487335]
4.	Imamura, T., Nitta, H., Wada, Y., Kobayashi, H. and Okamoto, K. Impaired plasma clottability induction through fibrinogen degradation by ASP, a serine protease released from Aeromonas sobria. FEMS Microbiol. Lett. 284 (2008) 35–42. [DOI] [PMID: 18462393]
5.	Nitta, H., Imamura, T., Wada, Y., Irie, A., Kobayashi, H., Okamoto, K. and Baba, H. Production of C5a by ASP, a serine protease released from Aeromonas sobria. J. Immunol. 181 (2008) 3602–3608. [DOI] [PMID: 18714034]

[EC 3.4.21.121 created 2013]