| EC |
3.4.21.21 |
| Accepted name: |
coagulation factor VIIa |
| Reaction: |
Selective cleavage of Arg┼Ile bond in factor X to form factor Xa |
| Other name(s): |
blood-coagulation factor VIIa; activated blood coagulation factor VII |
| Comments: |
Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human [1]. In peptidase family S1 (trypsin family) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 65312-43-8 |
| References: |
| 1. |
Nemerson, Y. and Esnouf, M.P. Activation of a proteolytic system by a membrane lipoprotein: mechanism of action of tissue factor. Proc. Natl. Acad. Sci. USA 70 (1973) 310–314. [DOI] [PMID: 4510277] |
| 2. |
Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. The role of serine proteases in the blood coagulation cascade. Adv. Enzymol. 48 (1979) 277–318. [PMID: 367103] |
| 3. |
Jackson, C.M. and Nemerson, Y. Blood coagulation. Annu. Rev. Biochem. 49 (1980) 765–811. [DOI] [PMID: 6996572] |
| 4. |
Broze, G.J., Jr. and Majerus, P.W. Human factor VII. Methods Enzymol. 80 (1981) 228–237. |
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| [EC 3.4.21.21 created 1978] |
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