ExplorEnz: EC 3.4.21.22

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3.4.21.22

Accepted name:

coagulation factor IXa

Reaction:

Selective cleavage of Arg┼Ile bond in factor X to form factor Xa

Other name(s):

activated Christmas factor; blood-coagulation factor IXa; activated blood-coagulation factor IX; autoprothrombin II; blood platelet cofactor II; activated blood coagulation factor XI

Comments:

A chymotrypsin homologue, and one of the γ-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family)

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 37316-87-3

References:

1.	Fujikawa, K. and Davie, E.W. Bovine factor IX (Christmas factor). Methods Enzymol. 45 (1976) 74–83. [DOI] [PMID: 1012029]
2.	Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. The role of serine proteases in the blood coagulation cascade. Adv. Enzymol. 48 (1979) 277–318. [PMID: 367103]
3.	Link, R.P. and Castellino, F.J. Kinetic comparison of bovine blood coagulation factor IXaα and IXaβ towards bovine factor X. Biochemistry 22 (1983) 4033–4041. [PMID: 6412750]
4.	Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. Biochemistry 23 (1984) 644–650. [PMID: 6370301]

[EC 3.4.21.22 created 1978]