The Enzyme Database

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Accepted name: cucumisin
Reaction: Hydrolysis of proteins with broad specificity
Other name(s): euphorbain; solanain; hurain; tabernamontanain
Comments: From the sarcocarp of the musk melon (Cucumis melo). In peptidase family S8 (subtilisin family). Other endopeptidases from plants, which are less well characterized but presumably of serine-type, include euphorbain from Euphorbia cerifera [6], solanain from horse-nettle Solanum elaeagnifolium [1], hurain from Hura crepitans [2] and tabernamontanain from Tabernamontana grandiflora [3].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 82062-89-3
1.  Greenberg, D.M. and Winnick, T. Plant proteases. I. Activation-inhibition reactions. J. Biol. Chem. 135 (1940) 761–773.
2.  Jaffé, W.G. Hurain, a new plant protease from Hura crepitans. J. Biol. Chem. 149 (1943) 1–7.
3.  Jaffé, W.G. A new vegetable proteolytic enzyme of the papain class. Rev. Brasil Biol. 3 (1943) 149–157.
4.  Kaneda, M. and Toninaga, N. Isolation and characterization of a proteinase from the sarcocarp of melon fruit. J. Biochem. (Tokyo) 78 (1975) 1287–1296. [PMID: 5423]
5.  Kaneda, M., Ohmine, H., Yonezawa, H. and Tominaga, N. Amino acid sequence around the reactive site of cucumisin from melon fruit. J. Biochem. (Tokyo) 95 (1984) 825–829. [PMID: 6427203]
6.  Lynn, K.R. and Clevette-Radford, N.A. Two proteases from the latex of Elaeophorbia drupifera. Phytochemistry 24 (1985) 2843–2845.
7.  Kaneda, N., Minematsu, Y., Powers, J.C. and Tominaga, N. Specificity of cucumisin in hydrolysis of peptide thiobenzyl esters. Agric. Biol. Chem. 50 (1986) 1075–1076.
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