The Enzyme Database

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Accepted name: prolyl oligopeptidase
Reaction: Hydrolysis of —Pro┼ and to a lesser extent —Ala┼ in oligopeptides
Other name(s): post-proline cleaving enzyme; proline-specific endopeptidase; post-proline endopeptidase; proline endopeptidase; endoprolylpeptidase; prolyl endopeptidase
Comments: Found in vertebrates, plants and Flavobacterium. Generally cytosolic, commonly activated by thiol compounds. Type example of peptidase family S9.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 72162-84-6
1.  Walter, R. and Yoshimoto, T. Postproline cleaving enzyme: kinetic studies of size and stereospecificity of its active site. Biochemistry 17 (1978) 4139–4144. [PMID: 708698]
2.  Nomura, K. Specificity of prolyl endopeptidase. FEBS Lett. 209 (1986) 235–237. [DOI] [PMID: 3539636]
3.  Moriyama, A., Nakanishi, M. and Sasaki, M. Porcine muscle prolyl endopeptidase and its endogenous substrates. J. Biochem. (Tokyo) 104 (1988) 112–117. [PMID: 2851585]
4.  Rennex, D., Hemmings, B.A., Hofsteenge, J. and Stone, S.R. cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue. Biochemistry 30 (1991) 2195–2203. [PMID: 1900195]
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