ExplorEnz: EC 3.4.21.27

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3.4.21.27

Accepted name:

coagulation factor XIa

Reaction:

Selective cleavage of Arg┼Ala and Arg┼Val bonds in factor IX to form factor IXa

Other name(s):

blood-coagulation factor XIa; activated blood-coagulation factor XI; activated plasma thromboplastin antecedent

Comments:

In peptidase family S1 (trypsin family), and one of the γ-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 37203-61-5

References:

1.	Kurachi, K. and Davie, E.W. Human factor XI (plasma thromboplastin antecedent). Methods Enzymol. 80 (1981) 211–220.
2.	Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. Biochemistry 23 (1984) 644–650. [PMID: 6370301]
3.	Fujikawa, K., Chung, D.W., Hendrickson, L.E. and Davie, E.W. Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein. Biochemistry 25 (1986) 2417–2424. [PMID: 3636155]

[EC 3.4.21.27 created 1978]