| EC |
3.4.21.38 |
| Accepted name: |
coagulation factor XIIa |
| Reaction: |
Selective cleavage of Arg┼Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa |
| Other name(s): |
Hageman factor (activated); blood-coagulation factor XIIf; activated β blood-coagulation factor XII; prealbumin activator; Hageman factor β-fragment; Hageman factor fragment HFf; blood-coagulation factor XIIaβ; prekallikrein activator; kallikreinogen activator |
| Comments: |
Also activates plasminogen and plasma prokallikrein. Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. In peptidase family S1 (trypsin family) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 75216-42-1 |
| References: |
| 1. |
Fujikawa, K. and Davie, E.W. Human factor XII (Hageman factor). Methods Enzymol. 80 (1981) 198–211. [PMID: 6918768] |
| 2. |
Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. Biochemistry 23 (1984) 644–650. [PMID: 6370301] |
| 3. |
Que, B.G. and Davie, E.W. Characterization of a cDNA coding for human factor XII (Hageman factor). Biochemistry 25 (1986) 1525–1528. [PMID: 3011063] |
| 4. |
Fujikawa, K. Bovine Hageman factor and its fragments. Methods Enzymol. 163 (1988) 54–68. [PMID: 3237089] |
| 5. |
Silverberg, M. and Kaplan, A.P. Human Hageman factor and its fragments. Methods Enzymol. 163 (1988) 68–80. [PMID: 3237092] |
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| [EC 3.4.21.38 created 1981] |
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