| EC |
3.4.21.41 |
| Accepted name: |
complement subcomponent C1r |
| Reaction: |
Selective cleavage of Lys(or Arg)┼Ile bond in complement subcomponent C1s to form C1s (EC 3.4.21.42) |
| Other name(s): |
activated complement C1r; C1r esterase |
| Comments: |
Activated from proenzyme C1r in plasma during activation of the complement system by the "classical" route. In peptidase family S1 (trypsin family) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 80295-69-8 |
| References: |
| 1. |
Sim, R.B. The human complement system serine proteases C1r and C1s and their proenzymes. Methods Enzymol. 80 (1981) 26–42. [PMID: 6281620] |
| 2. |
Leytus, S.P., Kurachi, K., Sakariassen, K.S. and Davie, E.W. Nucleotide sequence of the cDNA coding for human complement C1r. Biochemistry 25 (1986) 4855–4863. [PMID: 3021205] |
| 3. |
Müller-Eberhard, H.J. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57 (1988) 321–347. [DOI] [PMID: 3052276] |
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| [EC 3.4.21.41 created 1981] |
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