The Enzyme Database

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Accepted name: complement subcomponent C1r
Reaction: Selective cleavage of Lys(or Arg)┼Ile bond in complement subcomponent C1s to form C1s (EC
Other name(s): activated complement C1r; C1r esterase
Comments: Activated from proenzyme C1r in plasma during activation of the complement system by the "classical" route. In peptidase family S1 (trypsin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 80295-69-8
1.  Sim, R.B. The human complement system serine proteases C1r and C1s and their proenzymes. Methods Enzymol. 80 (1981) 26–42. [PMID: 6281620]
2.  Leytus, S.P., Kurachi, K., Sakariassen, K.S. and Davie, E.W. Nucleotide sequence of the cDNA coding for human complement C1r. Biochemistry 25 (1986) 4855–4863. [PMID: 3021205]
3.  Müller-Eberhard, H.J. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57 (1988) 321–347. [DOI] [PMID: 3052276]
[EC created 1981]

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