| EC |
3.4.21.42 |
| Accepted name: |
complement subcomponent C1s |
| Reaction: |
Cleavage of Arg┼Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)┼Lys bond in complement component C2 to form C2a and C2b: the "classical" pathway C3 convertase |
| Other name(s): |
C1 esterase; activated complement C1s; complement C1r |
| Comments: |
Activated from proenzyme C1s in plasma by complement subcomponent C1r. In peptidase family S1 (trypsin family) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 80295-70-1 |
| References: |
| 1. |
Sim, R.B. The human complement system serine proteases C1r and C1s and their proenzymes. Methods Enzymol. 80 (1981) 26–42. [PMID: 6281620] |
| 2. |
MacKinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B. and Fothergill, J.E. Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence. Eur. J. Biochem. 169 (1987) 547–553. [DOI] [PMID: 3500856] |
| 3. |
Müller-Eberhard, H.J. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57 (1988) 321–347. [DOI] [PMID: 3052276] |
| 4. |
Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P. The specificity of two proteinases that cleave adjacent to arginine, C 1 esterase and acrosin, for peptide p-nitroanilide substrates. Biochim. Biophys. Acta 996 (1989) 89–94. [DOI] [PMID: 2500154] |
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| [EC 3.4.21.42 created 1981] |
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