| EC |
3.4.21.46 |
| Accepted name: |
complement factor D |
| Reaction: |
Selective cleavage of Arg┼Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor |
| Other name(s): |
C3 proactivator convertase; properdin factor D esterase; factor D; factor D (complement) |
| Comments: |
A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C1s. In peptidase family S1 (trypsin family) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 37213-56-2 |
| References: |
| 1. |
Reid, K.B.M., Johnson, D.M.A., Gagnon, J. and Prohaska, R. Preparation of human factor D of the alternative pathway of complement. Methods Enzymol. 80 (1981) 134–143. [PMID: 6918766] |
| 2. |
Müller-Eberhard, H.J. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57 (1988) 321–347. [DOI] [PMID: 3052276] |
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| [EC 3.4.21.46 created 1981] |
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