The Enzyme Database

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Accepted name: cerevisin
Reaction: Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt Ac-Tyr-OEt. Does not hydrolyse peptide amides
Other name(s): yeast proteinase B; proteinase yscB (gene name); baker‘s yeast proteinase B; brewer’s yeast proteinase; peptidase β
Comments: From Saccharomyces cerevisiae (baker's yeast, brewer's yeast). In peptidase family S8 (subtilisin family), but contains a Cys residue near the active site His, and is inhibited by mercurials. Proteinase ycaB is a similar enzyme from the yeast Candida albicans [3]
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 37288-81-6
1.  Félix, F. and Brouillet, N. Purification et proprietes de deux peptidases de levure de brasserie. Biochim. Biophys. Acta 122 (1966) 127–144. [PMID: 4961236]
2.  Kominami, E., Hoffschulte, H., Leuschel, L., Maier, K. and Holzer, H. The substrate specificity of proteinase B from baker’s yeast. Biochim. Biophys. Acta 661 (1981) 136–141. [DOI] [PMID: 7028121]
3.  Farley, P.C., Shepherd, M.G. and Sullivan, P.A. The purification and properties of yeast proteinase B from Candida albicans. Biochem. J. 236 (1986) 177–184. [PMID: 3539100]
4.  Moehle, C.M., Tizard, R., Lemmon, S.K., Smart, J. and Jones, E.W. Protease B of the lysosome like vacuole of the yeast Saccharomyces cerevisiae is homologous to the subtilisin family of serine proteases. Mol. Cell. Biol. 7 (1987) 4390–4399. [DOI] [PMID: 3325823]
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