| EC |
3.4.21.49 |
| Accepted name: |
hypodermin C |
| Reaction: |
Hydrolysis of proteins including native collagen at ┼Ala bond leaving an N-terminal (75%) and a C-terminal (25%) fragment |
| Other name(s): |
Hypoderma collagenase |
| Comments: |
From the larva of a warble fly, Hypoderma lineatum. Little action on small molecule substrates of trypsin, chymotrypsin, elastase or microbial collagenases. In peptidase family S1 (trypsin family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 122191-36-0 |
| References: |
| 1. |
Lecroisey, A., Boulard, C. and Keil, B. Chemical and enzymatic characterization of the collagenase from the insect Hypoderma lineatum. Eur. J. Biochem. 101 (1979) 385–393. [DOI] [PMID: 230030] |
| 2. |
Lecroisey, A. and Keil, B. Specificity of the collagenase from the insect Hypoderma lineatum. Eur. J. Biochem. 152 (1985) 123–130. [DOI] [PMID: 2995028] |
| 3. |
Lecroisey, A., Gilles, A.-M., De Wolf, A. and Keil, B. Complete amino acid sequence of the collagenase from the insect Hypoderma lineatum. J. Biol. Chem. 262 (1987) 7546–7551. [PMID: 3034899] |
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| [EC 3.4.21.49 created 1981] |
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