| EC |
3.4.21.54 |
| Accepted name: |
γ-renin |
| Reaction: |
Cleavage of the Leu┼Leu bond in synthetic tetradecapeptide renin substrate (horse), to produce angiotensin I, but not active on natural angiotensinogen, unlike renin (EC 3.4.23.15). Also hydrolyses Bz-Arg-p-nitroanilide |
| Comments: |
A member of the tissue kallikrein family, from submandibular glands of male mice. In peptidase family S1 (trypsin family) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, CAS registry number: 85270-20-8 |
| References: |
| 1. |
Poe, M., Wu, J.K., Florance, J.R., Rodkey, J.A., Bennett, C.D. and Hoogsteen, K. Purification and properties of renin and γ-renin from the mouse submaxillary gland. J. Biol. Chem. 258 (1983) 2209–2216. [PMID: 6337154] |
| 2. |
Drinkwater, C.C., Evans, B.A. and Richards, R.I. Sequence and expression of mouse γ-renin. J. Biol. Chem. 263 (1988) 8565–8568. [PMID: 3288617] |
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| [EC 3.4.21.54 created 1986] |
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