The Enzyme Database

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Accepted name: t-plasminogen activator
Reaction: Specific cleavage of Arg┼Val bond in plasminogen to form plasmin
Other name(s): tissue plasminogen activator; plasminogen activator, tissue-type; tissue-type plasminogen activator; tPA; t-PA
Comments: A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC and EC
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 139639-23-9
1.  Pennica, D., Holmes, W.E., Kohr, W.J., Harkins, R.N., Vehar, G.A., Ward, C.A., Bennett, W.F., Yelverton, E., Seeburg, P.H., Heyneker, H.L., Goeddel, D.V. and Collen, D. Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature 301 (1983) 214–221. [PMID: 6337343]
2.  Loskutoff, D.J. and Schleef, R.R. Plasminogen activators and their inhibitors. Methods Enzymol. 163 (1988) 293–302. [PMID: 3148826]
3.  Petersen, L.C., Johannessen, M., Forster, D., Kumar, A. and Mulvihill, E. The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage. Biochim. Biophys. Acta 952 (1988) 245–254. [PMID: 2962643]
4.  Verheijen, J.H. Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma. Methods Enzymol. 163 (1988) 302–309. [PMID: 3148827]
5.  Gerard, R.D. and Meidell, R.S. Regulation of tissue plasminogen activator expression. Annu. Rev. Physiol. 51 (1989) 245–262. [DOI] [PMID: 2496643]
6.  Collen, D., Lijnen, H. R. and Verstraete, M. The fibrinolytic system and its disorders. In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Ed.), Blood: Principles and Practice of Hematology, 2nd edn, J.B.Lippincott Company, Philadelphia, 1990.
[EC created 1972 as EC, transferred 1978 as EC, part transferred 1992 to EC]

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