The Enzyme Database

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Accepted name: protein C (activated)
Reaction: Degradation of blood coagulation factors Va and VIIIa
Other name(s): blood-coagulation factor XIVa; activated blood coagulation factor XIV; activated protein C; autoprothrombin II-A; protein Ca; APC; GSAPC
Comments: A peptidase of family S1 (trypsin family), one of the γ-carboxyglutamic acid-containing coagulation factors. Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 42617-41-4
1.  Esmon, C.T. The regulation of natural anticoagulant pathways. Science 235 (1987) 1348–1352. [DOI] [PMID: 3029867]
2.  Esmon, C.T. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J. Biol. Chem. 264 (1989) 4743–4746. [PMID: 2538457]
[EC created 1992]

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