| EC |
3.4.21.70 |
| Accepted name: |
pancreatic endopeptidase E |
| Reaction: |
Preferential cleavage: Ala┼. Does not hydrolyse elastin |
| Other name(s): |
cholesterol-binding proteinase; proteinase E; cholesterol-binding serine proteinase; pancreatic protease E; pancreatic proteinase E; cholesterol-binding pancreatic proteinase; CBPP; pancreas E proteinase |
| Comments: |
A peptidase of family S1 (trypsin family) from pancreatic juice. Unlike elastases, has an acidic pI. Binds cholesterol |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, CAS registry number: 68073-27-8 |
| References: |
| 1. |
Mallory, P.A. and Travis, J. Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E, resembling elastase. Biochemistry 14 (1975) 722–729. [PMID: 234742] |
| 2. |
Shen, W., Fletcher, T.S. and Largman, C. Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA. Biochemistry 26 (1987) 3447–3452. [PMID: 3477287] |
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| [EC 3.4.21.70 created 1992] |
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