ExplorEnz: EC 3.4.21.71

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3.4.21.71

Accepted name:

pancreatic elastase II

Reaction:

Preferential cleavage: Leu┼, Met┼ and Phe┼. Hydrolyses elastin

Other name(s):

pancreatic elastase 2

Comments:

A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 75603-19-9

References:

1.	Fletcher, T.S., Shen, W.-F. and Largman, C. Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. Biochemistry 26 (1987) 7256–7261. [PMID: 3427074]
2.	Shirasu, Y., Yoshida, H., Matsuki, S., Takemura, K., Ikeda, N., Shimada, Y., Ozawa, T., Mikayama, T., Iijima, H., Ishida, A., Sato, Y., Tamai, Y., Tanaka, J. and Ikenaga, H. Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. J. Biochem. (Tokyo) 102 (1987) 1555–1563. [PMID: 2834346]

[EC 3.4.21.71 created 1992]