| EC |
3.4.21.72 |
| Accepted name: |
IgA-specific serine endopeptidase |
| Reaction: |
Cleavage of immunoglobulin A molecules at certain Pro┼ bonds in the hinge region. No small molecule substrates are known |
| Other name(s): |
IgA protease; IgA proteinase; IgA-specific proteinase; immunoglobulin A protease; immunoglobulin A proteinase |
| Comments: |
Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC 3.4.24.13, IgA-specific metalloendopeptidase) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 55127-02-1 |
| References: |
| 1. |
Plaut, A.G. The IgA1 proteases of pathogenic bacteria. Annu. Rev. Microbiol. 37 (1983) 603–622. [DOI] [PMID: 6416146] |
| 2. |
Bachovchin, W.W., Plaut, A.G., Flentke, G.R., Lynch, M. and Kettner, C.A. Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids. J. Biol. Chem. 265 (1990) 3738–3743. [PMID: 2105953] |
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| [EC 3.4.21.72 created 1992] |
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