The Enzyme Database

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Accepted name: IgA-specific serine endopeptidase
Reaction: Cleavage of immunoglobulin A molecules at certain Pro┼ bonds in the hinge region. No small molecule substrates are known
Other name(s): IgA protease; IgA proteinase; IgA-specific proteinase; immunoglobulin A protease; immunoglobulin A proteinase
Comments: Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC, IgA-specific metalloendopeptidase)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 55127-02-1
1.  Plaut, A.G. The IgA1 proteases of pathogenic bacteria. Annu. Rev. Microbiol. 37 (1983) 603–622. [DOI] [PMID: 6416146]
2.  Bachovchin, W.W., Plaut, A.G., Flentke, G.R., Lynch, M. and Kettner, C.A. Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids. J. Biol. Chem. 265 (1990) 3738–3743. [PMID: 2105953]
[EC created 1992]

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