ExplorEnz: EC 3.4.21.78

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3.4.21.78

Accepted name:

granzyme A

Reaction:

Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg┼, -Lys┼ >> -Phe┼ in small molecule substrates

Other name(s):

CTLA3; HuTPS; T-cell associated protease 1; cytotoxic T lymphocyte serine protease; TSP-1; T-cell derived serine proteinase

Comments:

From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe┼-

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 143180-73-8

References:

1.	Simon, M.M., Hoschützky, H., Fruth, U., Simon, H.-G. and Kramer, M.D. Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes. EMBO J. 5 (1986) 3267–3274. [PMID: 3545816]
2.	Gershenfeld, H.K., Hershberger, R.J., Shows, T.B. and Weissman, I.L. Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease. Proc. Natl. Acad. Sci. USA 85 (1988) 1184–1188. [DOI] [PMID: 3257574]
3.	Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J.T., Krahenbuhl, O., Tschopp, J. and Powers, J.C. Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry 30 (1991) 2217–2227. [PMID: 1998680]

[EC 3.4.21.78 created 1993]