ExplorEnz: EC 3.4.21.86

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3.4.21.86

Accepted name:

limulus clotting enzyme

Reaction:

Selective cleavage of -Arg¹⁸┼ and -Arg⁴⁷┼ bonds in coagulogen to form coagulin and fragments

Other name(s):

clotting enzyme

Comments:

From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor . In peptidase family S1 (trypsin family)

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, MEROPS

References:

1.	Muta, T., Hashimoto, R., Miyata, T., Nishimura, H., Toh, Y. and Iwanaga, S. Proclotting enzyme from horseshoe crab hemocytes. cDNA cloning, disulfide locations, and subcellular localization. J. Biol. Chem. 265 (1990) 22426–22433. [PMID: 2266134]
2.	Tokunaga, F., Nakajima, H. and Iwanaga, S. Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by α-chymotrypsin, not by trypsin. J. Biochem. (Tokyo) 109 (1991) 150–157. [PMID: 2016264]

[EC 3.4.21.86 created 1993]