| EC |
3.4.21.90 |
| Accepted name: |
togavirin |
| Reaction: |
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp┼Ser- bond |
| Other name(s): |
Sindbis virus protease; Sindbis virus core protein; NsP2 proteinase |
| Comments: |
Known from the Sindbis and Semliki forest togaviruses. Once released, the core protein does not retain catalytic activity. Togavirin is the type example of peptidase family S3 and has a similar tertiary structure to chymotrypsin [3] |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 342882-56-8 |
| References: |
| 1. |
Kräusslich, H.-G. and Wimmer, E. Viral proteinases. Annu. Rev. Biochem. 57 (1988) 701–754. [DOI] [PMID: 3052288] |
| 2. |
Strauss, E.G., De Groot, R.J., Levinson, R. and Strauss, J.H. Identification of the active site residues in the nsP2 proteinase of Sindbis virus. Virology 191 (1992) 932–940. [PMID: 1448929] |
| 3. |
Tong, L., Wengler, G. and Rossmann, M.G. Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures. J. Mol. Biol. 230 (1993) 228–247. [DOI] [PMID: 8450538] |
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| [EC 3.4.21.90 created 1995] |
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