| EC |
3.4.22.29 |
| Accepted name: |
picornain 2A |
| Reaction: |
Selective cleavage of Tyr┼Gly bond in picornavirus polyprotein |
| Other name(s): |
picornavirus endopeptidase 2A; poliovirus protease 2A; rhinovirus protease 2A; 2A protease; 2A proteinase; protease 2A; proteinase 2Apro; picornaviral 2A proteinase; Y-G proteinase 2A; poliovirus proteinase 2A; poliovirus protease 2Apro |
| Comments: |
From entero-, rhino-, aphto- and cardioviruses. Smaller than the homologous picornain 3C, which is also in peptidase family C3 (picornain 3C family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 103406-62-8 |
| References: |
| 1. |
Bazan, J.F. and Fletterick, R.J. Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications. Proc. Natl. Acad. Sci. USA 85 (1988) 7872–7876. [DOI] [PMID: 3186696] |
| 2. |
König, H. and Rosenwirth, B. Purification and partial characterization of poliovirus protease 2A by means of a functional assay. J. Virol. 62 (1988) 1243–1250. [PMID: 2831385] |
| 3. |
Kräusslich, H.-G. and Wimmer, E. Viral proteinases. Annu. Rev. Biochem. 57 (1988) 701–754. [DOI] [PMID: 3052288] |
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| [EC 3.4.22.29 created 1992] |
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