ExplorEnz: EC 3.4.23.15

Your query returned 1 entry. Printable version

3.4.23.15

Accepted name:

renin

Reaction:

Cleavage of Leu┼ bond in angiotensinogen to generate angiotensin I

Other name(s):

angiotensin-forming enzyme; angiotensinogenase

Comments:

Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9015-94-5

References:

1.	Inagami, T. and Murakami, K. Pure renin. Isolation from hog kidney and characterization. J. Biol. Chem. 252 (1977) 2978–2983. [PMID: 16012]
2.	Slater, E.E. Renin. Methods Enzymol. 80 (1981) 427–442. [PMID: 7043197]
3.	Inagami, T. Structure and function of renin. J. Hypertension 2) (1989) S3–S8. [PMID: 2666611]
4.	Sielecki, A.R., Hayakawa, K., Fujinaga, M., Murphy, M.E.P., Fraser, M., Muir, A.K., Carilli, C.T., Lewicki, J.A., Baxter, J.D. and James, M.N.G. Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 Å resolution. Science 243 (1989) 1346–1351. [DOI] [PMID: 2493678]

[EC 3.4.23.15 created 1961 as EC 3.4.4.15, transferred 1972 to EC 3.4.99.19, transferred 1981 to EC 3.4.23.15]