| EC |
3.4.23.17 |
| Accepted name: |
pro-opiomelanocortin converting enzyme |
| Reaction: |
Cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side |
| Other name(s): |
prohormone converting enzyme; pro-opiomelanocortin-converting enzyme; proopiomelanocortin proteinase; PCE |
| Comments: |
A 70 kDa membrane-bound enzyme isolated from cattle pituitary secretory vesicle. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 80891-34-5 |
| References: |
| 1. |
Loh, Y.P., Parish, D.C. and Tuteja, R. Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles. J. Biol. Chem. 260 (1985) 7194–7205. [PMID: 2987247] |
| 2. |
Loh, Y.P. Kinetic studies on the processing of human β-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme. J. Biol. Chem. 261 (1986) 11949–11955. [PMID: 3017955] |
| 3. |
Estivariz, F.E., Birch, N.P. and Loh, Y.P. Generation of Lys-γ3-melanotropin from pro-opiomelanocortin1-77 by a bovine intermediate lobe secretory vesicle membrane-associated aspartic protease and purified pro-opiomelanocortin converting enzyme. J. Biol. Chem. 264 (1989) 17796–17801. [PMID: 2553692] |
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| [EC 3.4.23.17 created 1989 as EC 3.4.99.38, transferred 1992 to EC 3.4.23.17] |
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