The Enzyme Database

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Accepted name: acrocylindropepsin
Reaction: Preference for hydrophobic residues at P1 and P1′. Action on the B chain of insulin is generally similar to that of pepsin A, but it also cleaves Leu6┼Cys(SO3H), Glu21┼Arg and Asn3┼Gln, although not Gln4-His
Other name(s): Acrocylindrium proteinase; Acrocylindrium acid proteinase
Comments: From the imperfect fungus Acrocylindrium sp. Has a very low pH optimum on casein of 2.0. In peptidase family A1 (pepsin A family).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37288-84-9
1.  Uchino, F., Kurono, Y. and Doi, S. Purification and some properties of crystalline acid protease from Acrocylindrium sp. Agric. Biol. Chem. 31 (1967) 428–434.
2.  Ichihara, S. and Uchino, F. The specificity of acid proteinase from Acrocylindrium. Agric. Biol. Chem. 39 (1975) 423–428.
3.  Takahashi, K. and Chang, W.-J. The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy)propane and pepstatin. J. Biochem. (Tokyo) 80 (1976) 497–506. [PMID: 10290]
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