EC |
3.4.23.30 |
Accepted name: |
pycnoporopepsin |
Reaction: |
Similar to pepsin A, but narrower, cleaving only three bonds in the B chain of insulin: Ala14┼Leu, Tyr16┼Leu, and Phe24┼Phe |
Other name(s): |
proteinase Ia; Pycnoporus coccineus aspartic proteinase; Trametes acid proteinase |
Comments: |
From the basidiomycete Pycnoporus sanguineus, formerly known as P. coccineus and Trametes sanguinea. Formerly included in EC 3.4.23.6 |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 77967-78-3 |
References: |
1. |
Tomoda, K. and Shimazono, H. Acid protease produced by Trametes sanguinea a wood-destroying fungus. Part I. Purification and crystallization of the enzyme. Agric. Biol. Chem. 28 (1964) 770–773. |
2. |
Tsuru, D., Hattori, A., Tsuji, H., Yamamoto, T. and Fukumoto, J. Studies on mold proteases. Part II. Substrate specificity of acid protease of Rhizopus chinensis. Agric. Biol. Chem. 33 (1969) 1419–1426. |
3. |
Ichishima, E., Kumagai, H. and Tomoda, K. Substrate specificity of carboxyl proteinase from Pycnoporus coccineus, a wood-deteriorating fungus. Curr. Microbiol. 3 (1980) 333–337. |
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[EC 3.4.23.30 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)] |
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