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Your query returned 1 entry. Printable version
EC | 3.4.23.46 | ||||
Accepted name: | memapsin 2 | ||||
Reaction: | Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu┼Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer'''s amyloid precursor protein | ||||
Other name(s): | β-secretase; β-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1) | ||||
Comments: | Suggested to be the major "β-secretase" responsible for the cleavage of the β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 158736-49-3 | ||||
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