ExplorEnz: EC 3.4.23.47

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3.4.23.47

Accepted name:

HIV-2 retropepsin

Reaction:

Endopeptidase for which the P1 residue is preferably hydrophobic

Comments:

In peptidase family A2. Responsible for the post-translational processing of the human immunodeficiency virus polyprotein.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 144114-21-6

References:

1.	Tözsér, J., Bláha, I., Copeland, T.D., Wondrak, E.M. and Oroszlan, S. Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins. FEBS Lett. 281 (1991) 77–80. [DOI] [PMID: 2015912]
2.	Chen, Z., Li, Y., Chen, E., Hall, D., Darke, P., Culberson, C., Shafer, J.A. and Kuo, L.A. Crystal structure at 1.9-Å resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J. Biol. Chem. 269 (1994) 26344–26348. [PMID: 7929352]

[EC 3.4.23.47 created 2003]