EC |
3.4.23.48 |
Accepted name: |
plasminogen activator Pla |
Reaction: |
Converts human Glu-plasminogen to plasmin by cleaving the Arg560┼Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins |
Comments: |
In peptidase family A26. From the bacterium Yersinia pestis that causes plague. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 101028-08-4 |
References: |
1. |
Kukkonen, M., Lähteenmäki, K., Suomalainen, M., Kalkkinen, N., Emödy, L., Laang, H. and Korhonen, T.K. Protein regions important for plasminogen activation and inactivation of α2-antiplasmin in the surface protease Pla of Yersinia pestis. Mol. Microbiol. 40 (2001) 1097–1111. [DOI] [PMID: 11401715] |
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[EC 3.4.23.48 created 2003] |
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