ExplorEnz: EC 3.4.23.50

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3.4.23.50

Accepted name:

human endogenous retrovirus K endopeptidase

Reaction:

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY┼PIVQ- cleavage site.

Other name(s):

human endogenous retrovirus K10 endopeptidase; endogenous retrovirus HERV-K10 putative protease; human endogenous retrovirus K retropepsin; HERV K10 endopeptidase; HERV K10 retropepsin; HERV-K PR; HERV-K protease; HERV-K113 protease; human endogenous retrovirus K113 protease; human retrovirus K10 retropepsin

Comments:

In peptidase family A2.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB

References:

Towler, E.M., Gulnik, S.V., Bhat, T.N., Xie, D., Gustschina, E., Sumpter, T.R., Robertson, N., Jones, C., Sauter, M., Mueller-Lantzsch, N., Debouck, C. and Erickson, J.W. Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease. Biochemistry 37 (1998) 17137–17144. [DOI] [PMID: 9860826]

[EC 3.4.23.50 created 2009]