The Enzyme Database

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Accepted name: IgA-specific metalloendopeptidase
Reaction: Cleavage of Pro┼Thr bond in the hinge region of the heavy chain of human IgA
Other name(s): immunoglobulin A1 proteinase; IgA protease; IgA1-specific proteinase; IgA1 protease; IgA1 proteinase
Comments: A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC, IgA-specific serine endopeptidase)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 72231-73-3
1.  Kornfeld, S.J. and Plaut, A.G. Secretory immunity and the bacterial IgA proteases. Rev. Infect. Dis. 3 (1981) 521–534. [PMID: 6792682]
2.  Gilbert, J.V., Plaut, A.G. and Wright, A. Analysis of the immunoglobulin A protease gene of Streptococcus sanguis. Infect. Immun. 59 (1991) 7–17. [PMID: 1987065]
3.  Gilbert, J.V., Plaut, A.G., Fishman, Y. and Wright, A. Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli. Infect. Immun. 56 (1988) 1961–1966. [PMID: 3294181]
[EC created 1984]

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