| EC |
3.4.24.14 |
| Accepted name: |
procollagen N-endopeptidase |
| Reaction: |
Cleaves the N-propeptide of collagen chain α1(I) at Pro┼Gln and of α1(II) and α2(I) at Ala┼Gln |
| Other name(s): |
procollagen N-terminal peptidase; procollagen aminopeptidase; aminoprocollagen peptidase; aminoterminal procollagen peptidase; procollagen aminoterminal protease; procollagen N-terminal proteinase; type I/II procollagen N-proteinase; type III procollagen |
| Comments: |
Removes the propeptides of type I and II collagens prior to fibril assembly. Does not act on type III collagen. In peptidase family M12 (astacin family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 68651-94-5 |
| References: |
| 1. |
Kohn, L.D., Iserky, C., Zupnik, J., Lenaers, A., Lee, G. and Lapiére, C.M. Calf tendon procollagen peptidase: its purification and endopeptidase mode of action. Proc. Natl. Acad. Sci. USA 71 (1974) 40–44. [DOI] [PMID: 4204204] |
| 2. |
Hojima, Y., McKenzie, J., van der Rest, M. and Prockop, D.J. Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides. J. Biol. Chem. 264 (1989) 11336–11345. [PMID: 2500439] |
|
| [EC 3.4.24.14 created 1984] |
| |
|
| |
|
Printable version