| EC |
3.4.24.29 |
| Accepted name: |
aureolysin |
| Reaction: |
Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1′ residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus |
| Other name(s): |
Staphylococcus aureus neutral proteinase; Staphylococcus aureus neutral protease |
| Comments: |
A metalloenzyme from S. aureus earlier confused with staphylokinase (a non-enzymic activator of plasminogen). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 39335-13-2 |
| References: |
| 1. |
Arvidson, S. Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease. Biochim. Biophys. Acta 302 (1973) 149–157. [DOI] [PMID: 4632563] |
| 2. |
Saheb, S.A. Purification et caractérisation d’une protéase extracellulaire de Staphylococcus aureus inhibée par l’E.D.T.A. Biochimie 58 (1976) 793–804. [DOI] [PMID: 823980] |
| 3. |
Drapeau, G.R. Role of a metalloprotease in activation of the precursor of staphylococcal protease. J. Bacteriol. 136 (1978) 607–613. [PMID: 711676] |
| 4. |
Potempa, J., Porwit-Bohr, Z. and Travis, J. Stabilization vs. degradation of Staphylococcus aureus metalloproteinase. Biochim. Biophys. Acta 993 (1989) 301–304. [DOI] [PMID: 2512988] |
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| [EC 3.4.24.29 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.29] |
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