| EC |
3.4.24.30 |
| Accepted name: |
coccolysin |
| Reaction: |
Preferential cleavage: ┼Leu, ┼Phe, ┼Tyr, ┼Ala |
| Other name(s): |
Streptococcus thermophilus intracellular proteinase; EM 19000 |
| Comments: |
A 30 kDa endopeptidase found intracellularly in S. thermophilus [1] and S. diacetilactis [2] and in the medium of S. faecalis [3,4]. In peptidase family M4 (thermolysin family). Formerly included in EC 3.4.24.4 |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, CAS registry number: 156859-08-4 |
| References: |
| 1. |
Desmazeaud, M.J. Propriétés générales et spécificité d’action d’une endopeptidase neutre intracellulaire de Streptococcus thermophilus. Biochimie 56 (1974) 1173–1181. [DOI] [PMID: 4451671] |
| 2. |
Desmazeaud, M.J. and Zevaco, C. General properties and substrate specificity of an intracellular neutral protease from Streptococcus diacetilactis. Ann. Biol. Anim. Biochem. Biophys. 16 (1976) 851–868. |
| 3. |
Smith, R.A.G., Green, J. and Kopper, P.H. The purification and properties of a fibrinolytic neutral metalloendopeptidase from Streptococcus faecalis. Arch. Biochem. Biophys. 202 (1980) 629–638. [DOI] [PMID: 6779709] |
| 4. |
Mäkinen, P.-L., Clewell, D.B., An, F., Mäkinen, K.K. Purification and substrate specificity of a strongly hydrophobic extracellular metalloendopeptidase ("gelatinase") from Streptococcus faecalis (strain 0G1-10). J. Biol. Chem. 264 (1989) 3325–3334. [PMID: 2536744] |
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| [EC 3.4.24.30 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.30] |
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