| EC |
3.4.24.46 |
| Accepted name: |
adamalysin |
| Reaction: |
Cleavage of Phe1┼Val, His5┼Leu, His10┼Leu, Ala14┼Leu, Leu15┼Tyr, and Tyr16┼Leu of insulin B chain |
| Other name(s): |
Crotalus adamanteus metalloendopeptidase; proteinase I and II; Crotalus adamanteus venom proteinase II; adamalysin II |
| Comments: |
From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 74812-51-4 |
| References: |
| 1. |
Kurecki, T., Laskowski, M., Sr. and Kress, L.F. Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human α1-proteinase inhibitor. J. Biol. Chem. 253 (1978) 8340–8345. [PMID: 309470] |
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| [EC 3.4.24.46 created 1992] |
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