The Enzyme Database

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Accepted name: ruberlysin
Reaction: Cleavage of His10┼Leu, Ala14┼Leu, Tyr16┼Leu and Gly23┼Phe bonds in the B chain of insulin; His┼Pro, Pro┼Phe, and Trp┼Ser of angiotensin I; and Gly┼Phe of Met enkephalin
Other name(s): Crotalus ruber metalloendopeptidase II; hemorrhagic toxin II
Comments: A 25 kDa hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber) that cleaves fibrinogen. In peptidase family M12 (astacin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 846020-01-7
1.  Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom. Arch. Biochem. Biophys. 253 (1987) 108–121. [DOI] [PMID: 2949699]
2.  Takeya, H., Onikura, A., Nikai, T., Sugihara, H. and Iwanaga, S. Primary structure of a hemorrhagic metalloproteinase, HT- 2, isolated from the venom of Crotalus ruber ruber. J. Biochem. (Tokyo) 108 (1990) 711–719. [PMID: 2081731]
[EC created 1992]

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