| EC |
3.4.24.52 |
| Accepted name: |
trimerelysin I |
| Reaction: |
Cleavage of only two bonds His10┼Leu and Ala14┼Leu in the insulin B chain |
| Other name(s): |
Trimeresurus metalloendopeptidase I; hemorrhagic proteinase HR1A; hemorrhagic metalloproteinase HR1A; metalloproteinase HR1A |
| Comments: |
A 60 kDa hemorrhagic endopeptidase of pI 4.4 from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 151125-16-5 |
| References: |
| 1. |
Omori-Satoh, T. and Sadahiro, S. Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts. Biochim. Biophys. Acta 580 (1979) 392–404. [DOI] [PMID: 518906] |
| 2. |
Yamakawa, Y. and Omori-Satoh, T. The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis). Toxicon 26 (1988) 227–231. [PMID: 3284004] |
| 3. |
Takeya, H., Oda, K., Miyata, T., Omori-Satoh, T. and Iwanaga, S. The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis. J. Biol. Chem. 265 (1990) 16068–16073. [PMID: 2398046] |
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| [EC 3.4.24.52 created 1992] |
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