The Enzyme Database

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Accepted name: mitochondrial intermediate peptidase
Reaction: Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion
Other name(s): mitochondrial intermediate precursor-processing proteinase; MIP
Comments: A homologue of thimet oligopeptidase. Natural substrates are precursor proteins that have already been processed by mitochondrial processing peptidase. In peptidase family M3 (thimet oligopeptidase family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 136447-30-8
1.  Isaya, G., Kalousek, F. and Rosenberg, L.E. Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase. J. Biol. Chem. 267 (1992) 7904–7910. [PMID: 1560019]
2.  Isaya, G., Kalousek, F. and Rosenberg, L.E. Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue. Proc. Natl. Acad. Sci. USA 89 (1992) 8317–8321. [DOI] [PMID: 1518864]
[EC created 1993]

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