ExplorEnz: EC 3.4.24.79

Your query returned 1 entry. Printable version

3.4.24.79

Accepted name:

pappalysin-1

Reaction:

Cleavage of the Met¹³⁵┼Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser¹⁴³┼Lys bond in IGFBP-5

Other name(s):

insulin-like growth factor binding protein-4 protease; pregnancy-associated plasma protein-A

Comments:

A 400-kDa disulfide-linked dimer. Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase. The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold. In peptidase family M43.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB

References:

1.	Lawrence, J.B., Oxvig, C., Overgaard, M.T., Sottrup-Jensen, L., Gleich, G.J. , Hays L.G., Yates, J.R. 3rd, and Conover, C.A. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc. Natl. Acad. Sci. USA 96 (1999) 3149–3153. [DOI] [PMID: 10077652]
2.	Chen, B.K., Overgaard, M.T., Bale, L.K., Resch, Z.T., Christiansen, M., Oxvig, C. and Conover, C.A. Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor. Endocrinology 143 (2002) 1199–1205. [DOI] [PMID: 11897673]

[EC 3.4.24.79 created 2003]