ExplorEnz: EC 3.5.1.110

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3.5.1.110

Accepted name:

ureidoacrylate amidohydrolase

Reaction:

(1) (Z)-3-ureidoacrylate + H₂O = (Z)-3-aminoacrylate + CO₂ + NH₃ (overall reaction)
(1a) (Z)-3-ureidoacrylate + H₂O = (Z)-3-aminoacrylate + carbamate
(1b) carbamate = CO₂ + NH₃ (spontaneous)
(2) (Z)-2-methylureidoacrylate + H₂O = (Z)-2-methylaminoacrylate + CO₂ + NH₃ (overall reaction)
(2a) (Z)-2-methylureidoacrylate + H₂O = (Z)-2-methylaminoacrylate + carbamate
(2b) carbamate = CO₂ + NH₃ (spontaneous)

For diagram of pyrimidine catabolism, click here

Glossary:

(Z)-3-ureidoacrylate = (2Z)-3-(carbamoylamino)prop-2-enoate
(Z)-2-methylureidoacrylate = (2Z)-3-(carbamoylamino)-2-methylprop-2-enoate

Other name(s):

peroxyureidoacrylate/ureidoacrylate amidohydrolase; rutB (gene name); (Z)-3-ureidoacrylate peracid amidohydrolase

Systematic name:

(Z)-3-ureidoacrylate amidohydrolase

Comments:

The enzyme participates in the Rut pyrimidine catabolic pathway.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Kim, K.S., Pelton, J.G., Inwood, W.B., Andersen, U., Kustu, S. and Wemmer, D.E. The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. J. Bacteriol. 192 (2010) 4089–4102. [DOI] [PMID: 20400551]

[EC 3.5.1.110 created 2012, modified 2020]