The Enzyme Database

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Accepted name: 1-carboxybiuret hydrolase
Reaction: 1-carboxybiuret + H2O = urea-1,3-dicarboxylate + NH3
For diagram of atrazine catabolism, click here
Glossary: carboxybiuret = carbamoylcarbamoylcarbamic acid
Other name(s): atzEG (gene names)
Systematic name: 1-carboxybiuret amidohydrolase
Comments: The enzyme, characterized from the bacterium Pseudomonas sp. ADP, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazine herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is a heterotetramer composed of a catalytic subunit (AtzE) and an accessory subunit (AtzG) that stabilizes the complex.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Esquirol, L., Peat, T.S., Wilding, M., Liu, J.W., French, N.G., Hartley, C.J., Onagi, H., Nebl, T., Easton, C.J., Newman, J. and Scott, C. An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme. J. Biol. Chem. 293 (2018) 7880–7891. [DOI] [PMID: 29523689]
[EC created 2019]

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