ExplorEnz: EC 3.5.1.24

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3.5.1.24

Accepted name:

choloylglycine hydrolase

Reaction:

glycocholate + H₂O = cholate + glycine

For diagram of cholic acid conjugates biosynthesis, click here

Glossary:

glycocholate = N-(3α,7α,12α-trihydroxy-5β-cholan-24-oyl)glycine
cholate = 3α,7α,12α-trihydroxy-5β-cholan-24-oate

Other name(s):

glycocholase; bile salt hydrolase; choloyltaurine hydrolase; 3α,7α,12α-trihydroxy-5β-cholan-24-oylglycine amidohydrolase

Systematic name:

glycocholate amidohydrolase

Comments:

Also acts on the 3α,12α-dihydroxy-derivative, and on choloyl-taurine.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37289-07-9

References:

1.	Nair, P.P., Gordon, M. and Reback, J. The enzymatic cleavage of the carbon-nitrogen bond in 3α,7α,12α-trihydroxy-5-β-cholan-24-oylglycine. J. Biol. Chem. 242 (1967) 7–11. [PMID: 6016335]
2.	Stellwag, E.J. and Hylemon, P.B. Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis. Biochim. Biophys. Acta 452 (1976) 165–176. [DOI] [PMID: 10993]

[EC 3.5.1.24 created 1972]