| EC |
3.5.1.36 |
| Accepted name: |
N-methyl-2-oxoglutaramate hydrolase |
| Reaction: |
N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine |
| Other name(s): |
5-hydroxy-N-methylpyroglutamate synthase |
| Systematic name: |
N-methyl-2-oxoglutaramate methylamidohydrolase |
| Comments: |
In the reverse reaction, the product cyclizes non-enzymically to 2-hydroxy-N-methyl-5-oxo-L-proline. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 9073-53-4 |
| References: |
| 1. |
Hersh, L.B. 5-Hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action. J. Biol. Chem. 245 (1970) 3526–3535. [PMID: 5470822] |
| 2. |
Hersh, L.B., Tsai, L. and Stadtman, E.R. The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid. J. Biol. Chem. 244 (1969) 4677–4683. [PMID: 5808511] |
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| [EC 3.5.1.36 created 1972] |
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