ExplorEnz: EC 3.5.1.92

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3.5.1.92

Accepted name:

pantetheine hydrolase

Reaction:

(R)-pantetheine + H₂O = (R)-pantothenate + 2-aminoethanethiol

Other name(s):

pantetheinase; vanin; vanin-1

Systematic name:

(R)-pantetheine amidohydrolase

Comments:

The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B₅) and produces 2-aminoethanethiol (cysteamine), a potent anti-oxidant [5].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 56093-18-6

References:

1.	Duprè, S. and Cavallini, D. Purification and properties of pantetheinase from horse kidney. Methods Enzymol. 62 (1979) 262–267. [PMID: 440106]
2.	Duprè, S., Chiaraluce, R., Nardini, M., Cannella, C., Ricci, G. and Cavallini, D. Continuous spectrophotometric assay of pantetheinase activity. Anal. Biochem. 142 (1984) 175–181. [DOI] [PMID: 6549111]
3.	Maras, B., Barra, D., Duprè, S. and Pitari, G. Is pantetheinase the actual identity of mouse and human vanin-1 proteins? FEBS Lett. 461 (1999) 149–152. [DOI] [PMID: 10567687]
4.	Aurrand-Lions, M., Galland, F., Bazin, H., Zakharyev, V.M., Imhof, B.A. and Naquet, P. Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. Immunity 5 (1996) 391–405. [DOI] [PMID: 8934567]
5.	Pitari, G., Malergue, F., Martin, F., Philippe, J.M., Massucci, M.T., Chabret, C., Maras, B., Duprè, S., Naquet, P. and Galland, F. Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice. FEBS Lett. 483 (2000) 149–154. [DOI] [PMID: 11042271]
6.	Martin, F., Malergue, F., Pitari, G., Philippe, J.M., Philips, S., Chabret, C., Granjeaud, S., Mattei, M.G., Mungall, A.J., Naquet, P. and Galland, F. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. Immunogenetics 53 (2001) 296–306. [PMID: 11491533]
7.	Pace, H.C. and Brenner, C. The nitrilase superfamily: classification, structure and function. Genome Biol. 2 (2001) 0001.. [PMID: 11380987]

[EC 3.5.1.92 created 2006]