ExplorEnz: EC 3.5.2.20

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3.5.2.20

Accepted name:

isatin hydrolase

Reaction:

isatin + H₂O = isatinate

Glossary:

isatin = 1H-indole-2,3-dione
isatinate = 2-(2-aminophenyl)-2-oxoacetate

Systematic name:

isatin amidohydrolase

Comments:

Requires Mn²⁺. This enzyme, found in several bacterial species, is involved in the degradation of indole-3-acetic acid.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Sommer, M.R. and Jochimsen, B. Identification of enzymes involved in indole-3-acetic acid degradation. Plant Soil 186 (1996) 143–149.
2.	Bjerregaard-Andersen, K., Sommer, T., Jensen, J.K., Jochimsen, B., Etzerodt, M. and Morth, J.P. A proton wire and water channel revealed in the crystal structure of isatin hydrolase. J. Biol. Chem. 289 (2014) 21351–21359. [DOI] [PMID: 24917679]

[EC 3.5.2.20 created 2014]