ExplorEnz: EC 3.5.4.17

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3.5.4.17

Accepted name:

adenosine-phosphate deaminase

Reaction:

(1) AMP + H₂O = IMP + NH₃
(2) ADP + H₂O = IDP + NH₃
(3) ATP + H₂O = ITP + NH₃

Glossary:

IMP = inosine 5′-phosphate
AMP = adenosine 5′-phosphate

Other name(s):

adenylate deaminase; adenine nucleotide deaminase; adenosine (phosphate) deaminase

Systematic name:

adenosine-phosphate aminohydrolase

Comments:

Acts on AMP, ADP, ATP, NAD⁺ and adenosine, in decreasing order of activity. The bacterial enzyme can also accept the deoxy derivatives. cf. EC 3.5.4.6, AMP deaminase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37289-20-6

References:

1.	Su, J.-C., Li, C.-C. and Ting, C.C. A new adenylate deaminase from red marine alga Porphyra crispata. Biochemistry 5 (1966) 536–543. [PMID: 5940938]
2.	Yates, M.G. A non-specific adenine nucleotide deaminase from Desulfovibrio desulfuricans. Biochim. Biophys. Acta 171 (1969) 299–310. [DOI] [PMID: 5773435]

[EC 3.5.4.17 created 1972, modified 1980, modified 2014]