| EC |
3.5.4.19 |
| Accepted name: |
phosphoribosyl-AMP cyclohydrolase |
| Reaction: |
1-(5-phospho-β-D-ribosyl)-AMP + H2O = 1-(5-phospho-β-D-ribosyl)-5-[(5-phospho-β-D-ribosylamino)methylideneamino]imidazole-4-carboxamide |
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For diagram of histidine biosynthesis (early stages), click here |
| Other name(s): |
PRAMP-cyclohydrolase; phosphoribosyladenosine monophosphate cyclohydrolase; 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase |
| Systematic name: |
1-(5-phospho-β-D-ribosyl)-AMP 1,6-hydrolase |
| Comments: |
The Neurospora crassa enzyme also catalyses the reactions of EC 1.1.1.23 (histidinol dehydrogenase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37289-22-8 |
| References: |
| 1. |
Minson, A.C. and Creaser, E.H. Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa. Biochem. J. 114 (1969) 49–56. [PMID: 4309307] |
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| [EC 3.5.4.19 created 1972, modified 1976, modified 1981, modified 2000] |
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