| EC |
3.5.4.30 |
| Accepted name: |
dCTP deaminase (dUMP-forming) |
| Reaction: |
dCTP + 2 H2O = dUMP + diphosphate + NH3 |
| Systematic name: |
dCTP aminohydrolase (dUMP-forming) |
| Comments: |
Requires Mg2+. Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13, dCTP deaminase and EC 3.6.1.23, dUTP diphosphatase), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. This enzyme can also act as a dUTP diphosphatase, but more slowly. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Li, H., Xu, H., Graham, D.E. and White, R.H. The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase. J. Biol. Chem. 278 (2003) 11100–11106. [DOI] [PMID: 12538648] |
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| [EC 3.5.4.30 created 2003] |
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